A clinical study is happening across the US to explore an investigational treatment option for patients who experience prolonged life-threatening seizures.

healthcare technology and medicine concept. stethoscope on medical document and doctor studying and diagnostic data of patient for treatment.

About Status Epilepticus & Established Status Epilepticus

Status epilepticus (SE) is the most severe form of epilepsy and is a neurological emergency that requires urgent treatment to avoid possible permanent brain damage, death or other lasting problems. The diagnosis of status epilepticus is considered when someone has a seizure for longer than five minutes OR has two or more seizures occurring within a five-minute time span without returning to a normal level of consciousness between the seizures. 

Based on SE duration and response to treatment, it is divided into four stages: early, established, refractory and super-refractory status epilepticus. For this clinical study, the RESET study, investigators are looking at the second stage of SE, established status epilepticus (ESE), which is defined as SE that persists despite the first-line treatment (usually with benzodiazepine). Based on a variety of factors such as cause, age, and duration of the seizure, approximately 3% – 26% of patients with SE do not survive. Since longer seizures lead to greater risk of injury and death, it is important to treat patients experiencing SE as quickly as possible to try to stop the seizures.

SE is the second most common neurologic emergency in the US and there are over 150,000 patients in the US that have experienced SE.

There is a significant proportion of both children and adults with SE that have prior history of epilepsy, however, it is not possible to predict who will have SE or identify who is at risk since as many as half (50%) of patients with SE have never had it before.

Participating Sites

Henry Wang, MD
Ohio State Wexner Medical Center
376 W. 10th Ave, 725 Prior Hall
Columbus, OH 43210

Cookies Statement

Your choice regarding cookies on this site

We use cookies to optimize site functionality and give you the best experience. Necessary cookies enable core functionality. The website cannot function properly without these cookies, and can only be disabled by changing your browser preferences.

For more detailed information on the cookies we use, please check our Privacy Policy.

By continuing to access this website you are giving us consent to collect cookies.